Comparison of All-Cause Healthcare Resource Utilization Rates between Patients with Type 2 Diabetes Who Use a Digital Diabetes Solution Versus Non-Users: A 12-Month Retrospective Cohort Study


Wilson L1, Malone D2, Potukuchi P1, Thingalaya N1, Lee K3, Edwards A4, Yu X5, Lee F1, Kennedy A1, Han-Burgess E6, Brixner D2
1Sanofi, Bridgewater, NJ, USA, 2University of Utah College of Pharmacy, Salt Lake City, UT, USA, 3Sanofi, Reading, UK, 4Symphony Health, ICON plc, Blue Bell, PA, USA, 5Symphony Health, ICON plc, Yardley, USA, 6Sanofi, Cambridge, MA, USA


Dario Diabetes Solution (DDS) is a digital health application (app) for type 2 diabetes mellitus (T2DM) management. It combines a blood glucose (BG) meter and a mobile app, allowing patients to track BG levels in real-time. This study compared healthcare resource utilization (HCRU) by DDS users versus matched non-user cohort.


This retrospective cohort study (January 2017–April 2021) included adults (≥18 years) with T2DM receiving anti-diabetic medication(s) with ≥1 inpatient or ≥2 outpatient visits ≥30 days apart during baseline period. Baseline was 12 months before index date (first DDS registration [users] or first medical encounter in the quarter with medical claims [non-users]); follow-up was 12 months. User and non-user cohorts were matched 1:3 using exact and propensity score matching. Analysis included patients with access to care 12 months pre- and post-index date. Primary endpoint was all-cause HCRU (inpatient hospitalizations + ER visits) rates during follow-up. Data were analyzed using a generalized linear model with negative binomial distribution.


Of 9779 patients, DDS users (n=2445) and non-users (n=7334) were matched; mean±SD age was 58.2±10.6 and 58.3±12.5 years, respectively. At 12 months, mean (95% CI) all-cause HCRU rate (inpatient hospitalization + ER visits) was 0.475 (0.438–0.516) and 0.524 (0.500–0.549) events/year for users and non-users, respectively. Users had 9.3% lower HCRU rate compared with non-users (incidence rate ratio [IRR], 0.907 [0.826–0.996]; P=0.04). Mean all-cause inpatient hospitalization rate was 0.166 (0.147–0.186) and 0.216 (0.203–0.230) events/year for users and non-users, respectively. Users had 23.5% lower inpatient hospitalization incident rate versus non-users (IRR, 0.765 [0.671–0.873]; P<0.0001); ER visit rates were similar in both cohorts (IRR, 1.01 [0.907–1.125]; P=0.86).


In this retrospective cohort study, utilizing DDS demonstrated a significantly greater reduction in all-cause HCRU and inpatient hospitalization rates during 12-month follow-up compared with non-users receiving usual care.

Conference/Value in Health Info

2023-05, ISPOR 2023, Boston, MA, USA

Value in Health, Volume 26, Issue 6, S2 (June 2023)




Economic Evaluation, Medical Technologies


Medical Devices

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