Patient Reported Outcomes With Chemotherapy of Breast Cancer: An Analysis of Breast Cancer Registry Publications Between 2012-2022


Ali Hashmi MA1, Hussain SF1, Kachigalla N1, Rafiuddin M1, Bhavanasai S1, Pesara NS1, Kaushik M1, Jan R1, Vallish BN1, Dang A2
1MarksMan Healthcare Communications, Hyderabad, India, 2MarksMan Healthcare Communications, Hyderabad, AP, India

OBJECTIVES: To evaluate the nature and extent of reporting of patient-reported outcomes (PROs) among patients with breast cancer undergoing chemotherapy (with or without other types of therapies) in published registry audit articles

METHODS: After prospectively registering the study protocol with the Open Science Framework, we searched PubMed for relevant records published between 1-Jan-2012 and 21-Jun-2022 using appropriate search strategies. Publication details, demographics, intervention details, and details of PROs were extracted from eligible records.

RESULTS: Out of 522 records screened, 17 studies (10 cross-sectional studies; 4 prospective and 3 retrospective observational studies) involving 7001 women with different types and stages of breast cancer were included. A total of 19 registries from 8 countries were analyzed by the studies; 11 registries were from USA; 10 were hospital-based and 7 were population-based registries. The included studies evaluated a total of 44 PROs (17 unique PROs), the two most frequent being HRQOL and symptoms (17 and 5 studies respectively). Thirty-six different PRO scales were used, of which most frequently used were SF-36 (4 studies), FACT-B and FACT-G (3 studies each) for HRQoL, and HADS for anxiety-depression (3 studies). Only 4 studies measured PROs in pairs for before-after comparison

CONCLUSIONS: Recording and analyzing PROs in breast cancer registry audit papers is inadequate and has a large amount of variation

Systematic review protocol registration: OSF []

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)




STA: Drugs

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