A Head-to-Head Comparison of the EQ-5D-5L and 15D Descriptive Systems and Index Scores in a General Population Sample


Nikl A1, Janssen B2, Brodszky V3, Rencz F3
1Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine, Dunaföldvár, TO, Hungary, 2Erasmus MC, Section Medical Psychology and Psychotherapy, Department of Psychiatry, Rotterdam, Netherlands, 3Corvinus University of Budapest, Department of Health Economics, Budapest, PE, Hungary

Presentation Documents

OBJECTIVES: The EQ-5D-5L and 15D are generic preference-accompanied health status measures with similar dimensions. In this study, we aim to compare the measurement properties of the EQ-5D-5L and 15D descriptive systems and index scores in a large general population sample.

METHODS: In August 2021, an online cross-sectional survey was conducted in a nationally representative adult general population sample in Hungary (n=1887). The EQ-5D-5L and 15D descriptive systems and index scores were compared in terms of ceiling and floor effects, informativity (Shannon’s evenness index), agreement, convergent validity and known-groups validity for 20 different chronic physical and mental health conditions. Danish value sets were used to compute index scores for both instruments.

RESULTS: Among the corresponding dimensions, both the ceiling and floor effects were smaller for the EQ-5D-5L in most dimension pairs (exceptions: EQ-5D-5L anxiety/depression vs. 15D distress for the floor effect, and EQ-5D-5L anxiety/depression vs. 15D depression for the ceiling effect). The 15D index scores showed smaller ceiling effect than the EQ-5D-5L (21% vs. 36%). The average informativity was better for the EQ-5D-5L dimensions (0.56 vs. 0.49). A strong correlation was found between the EQ-5D-5L and 15D index scores (r=0.671). In most cases, the EQ-5D-5L was able to better discriminate between healthy respondents and those with chronic diseases; however, the difference in relative efficiency was insignificant in 18/20 condition groups (exceptions: thyroid diseases and gastroesophageal reflux disease).

CONCLUSIONS: This is the first study to compare the measurement properties of the EQ-5D-5L and 15D in a general population sample. The EQ-5D-5L performs better than the 15D for most measurement properties. Our findings help to understand the differences between the EQ-5D-5L and 15D instruments and index scores and provide broad information for health economic evaluations and resource allocation decisions.

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)




Methodological & Statistical Research, Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes, Survey Methods


No Additional Disease & Conditions/Specialized Treatment Areas

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