Impact of Pharmacist-Led Interventions on Health-Related Quality of Life in Diabetic Patients: Evidence From a Randomized Controlled Trial
Author(s)
Saad S. Alqahtani, BSc, MSc, PhD1, Muhammad Iqbal, PhD Clinical Pharmacy2.
1Associate Professor, King Khalid University, Abha, Saudi Arabia, 2King Khalid University, Abha, Saudi Arabia.
1Associate Professor, King Khalid University, Abha, Saudi Arabia, 2King Khalid University, Abha, Saudi Arabia.
OBJECTIVES: Objective of the present study was to evaluate the effect of pharmacist-led educational intervention on the diabetic patient-reported quality of life upon all the domains of EQ-5D.
METHODS: Two equal study arms after being recruited from the hospitals randomly. The controlled group consisted of 200 diabetic patients getting regular treatment from the hospitals. Whereas, the interventional group comprised of those 200 diabetic patients who were receiving the pharmacist collaborative care from DMTAC clinics along with the routine diabetic management and treatment. The study duration was of 1 year and consisted of two follow up visits for both study arms. A generic health related quality of life tool EQ-5D was used for exploring and examining the study data. ANCOVA and the Logistic binary regression analysis have been used for data analysis
RESULTS: The mean glycated haemoglobin-HbA1c was decreased to 1.44% in control group, whereas, a decrease of 2.84% was seen in interventional study arm. A statistically significant betterment in glycated haemoglobin level was seen in the interventional study arm i.e., p0.05. However, all the domains of the questionnaire-EQ-5D 5L conferred significant association with the health related quality of life parameters (p<0.05). Moreover, in control study arm a statistically significant enhancement is seen related to average scores of health related quality of life reported by patients on the Visual Analogue Scale (VAS) from 55.89±7.52 to 64.86±5.04. Moreover, the average scores have been ranged from 54.45±8.81 to 72.23±6.41 among interventional study arm i.e., F statistics 118.67 (1, 292) along with p<0.001.
CONCLUSIONS: The effect of pharmacist involvement in the form of intervention provision presented a positive improvement and statistically significant enhancement on every domain of the questionnaire-EQ-5D. The pharmacist collaborative care in the form of intervention turned out effective in enhancing the patient reported quality of life as well as in improving glycated haemoglobin (HbA1c) levels
METHODS: Two equal study arms after being recruited from the hospitals randomly. The controlled group consisted of 200 diabetic patients getting regular treatment from the hospitals. Whereas, the interventional group comprised of those 200 diabetic patients who were receiving the pharmacist collaborative care from DMTAC clinics along with the routine diabetic management and treatment. The study duration was of 1 year and consisted of two follow up visits for both study arms. A generic health related quality of life tool EQ-5D was used for exploring and examining the study data. ANCOVA and the Logistic binary regression analysis have been used for data analysis
RESULTS: The mean glycated haemoglobin-HbA1c was decreased to 1.44% in control group, whereas, a decrease of 2.84% was seen in interventional study arm. A statistically significant betterment in glycated haemoglobin level was seen in the interventional study arm i.e., p0.05. However, all the domains of the questionnaire-EQ-5D 5L conferred significant association with the health related quality of life parameters (p<0.05). Moreover, in control study arm a statistically significant enhancement is seen related to average scores of health related quality of life reported by patients on the Visual Analogue Scale (VAS) from 55.89±7.52 to 64.86±5.04. Moreover, the average scores have been ranged from 54.45±8.81 to 72.23±6.41 among interventional study arm i.e., F statistics 118.67 (1, 292) along with p<0.001.
CONCLUSIONS: The effect of pharmacist involvement in the form of intervention provision presented a positive improvement and statistically significant enhancement on every domain of the questionnaire-EQ-5D. The pharmacist collaborative care in the form of intervention turned out effective in enhancing the patient reported quality of life as well as in improving glycated haemoglobin (HbA1c) levels
Conference/Value in Health Info
2025-09, ISPOR Real-World Evidence Summit 2025, Tokyo, Japan
Value in Health Regional, Volume 49S (September 2025)
Code
RWD15
Topic Subcategory
Data Protection, Integrity, & Quality Assurance
Disease
SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity)