Presentation (CTI)

OBJECTIVES: Iron deficiency anemia (IDA) is a common condition that often requires intravenous (IV) iron therapy when oral iron is ineffective or poorly tolerated. The efficacy and safety of Ferric derisomaltose (FDI) was evaluated in the PROVIDE and FERWON-IDA trials demonstrating greater effectiveness compared to iron sucrose (IS) in achieving rapid hemoglobin improvement. Additionally, FDI allowed for higher cumulative dosing with fewer administrations. This study aimed to collect real-world data on the usage and costs of IV iron products in Ontario hospitals, including the evaluation of healthcare resource utilization (HCRU) and societal impacts of managing IDA.
METHODS: A survey was performed with seven pharmacists in Ontario hospitals. Five pharmacists reported data for the outpatient setting while three reported inpatient data. The costing model was developed over a 1-year time horizon, from a hospital perspective, including costs associated with treatment acquisition, preparation, administration and monitoring. The societal perspective was also assessed.
RESULTS: From a hospital perspective, total patient costs were estimated at $681 for FDI and $1,223 for IS, representing cost savings of $543/patient with FDI. From a societal perspective, FDI leads to costs savings of $1,027/patient. Annually, in a real-world setting, each hospital treats on average 889 IDA outpatients and 923 inpatients. Compared to a scenario without FDI, implementing FDI at a utilization rate of 51% resulted in savings of $254,499 in the outpatient setting. For inpatients, implementing FDI at 33% saved $161,345. From a societal perspective, FDI led to savings of $504,547 and $365,693, for outpatients and inpatients, respectively. FDI resulted in overall cost savings by reducing HCRU, increasing patient capacity, nurse efficiency and saving patient time, compared to IS.
CONCLUSIONS: FDI offers substantial cost savings compared to IS. Increased utilization of FDI is projected to increase total costs savings as well as valuable time savings for Ontario hospitals.