Multi-center RWE Hubs are enabling large-scale evidence generation across various therapeutic areas (i.e. cardio, onco, neuro) in Belgium, France, and Germany. Georges De Feu (LynxCare) and Jean-Baptiste Angeloglou (PSIH) will share how these federated clinical data networks create value for patients, clinicians, and researchers. Clara Oeste (LynxCare) will showcase how these insights are being used to identify patients at-risk of rare diseases through A.I. and NLP. LynxCare works with leading hospitals in Europe and the United States, and facilitates scientific research for Life Sciences companies such as AstraZeneca, Pfizer and Novartis within a strict ethical and legal framework.