Clinical Effectiveness Innovative Insulin Delivery Devices Compared with Conventional Therapy for Patients with Diabetes Mellitus: A Systematic Review and Meta Analysis

Author(s)

ABSTRACT WITHDRAWN

OBJECTIVES: Diabetes mellitus is a chronic metabolic disease defined by persistently elevated blood glucose levels. Patients with type 1 Diabetes mellitus are considered in the review. Type 1 diabetes is characterized by destruction of pancreatic beta cells, typically secondary to an autoimmune process. Hence, to evaluate the clinical effectiveness of innovative insulin delivery device- insulin pen compared with conventional therapy for patients with type 1 Diabetes mellitus.

METHODS: A comprehensive search was performed at various electronic databases using PubMed, Web of Science, Google Scholar, and Cochrane. A PRISMA method is used to curate and collocate the studies. Quantitative data were pooled into statistical meta-analyses using the Cochrane Review Manager (RevMan) to compare clinical efficacy innovative insulin delivery device -insulin pens versus conventional therapy.

RESULTS: A total of 3123 articles were obtained and after evaluation, 26 articles were accepted that answered the research questions and met the criteria for systematic review and meta-analysis. Therefore, the outcomes for the metanalysis with mean difference HbA1, (-0.62, 95% CI: -0.85, -0.40) and risk ratio for diabetic ketoacidosis (DKA) (1.29, 95% confidence interval 0.62 to 2.69) and severe hypoglycemia (0.79, 95% confidence interval 0.67 to 0.94) we found that moderate evidence for innovative delivery device-insulin pen slightly decreased HbA1c, DKA, and severe hypoglycemia compared with conventional therapy.

CONCLUSIONS: In this review we found that Innovative insulin delivery device -Insulin pens played an important role in patients’ recovery and decreased HbA1c, DKA, and severe hypoglycemia. Potential use of pen injectors improves glycemic control in type 1 diabetes compared with conventional therapy. This adds to the confidence that innovative delivery device-insulin pen will become more prevalent in the next few years.

Conference/Value in Health Info

2023-11, ISPOR Europe 2023, Copenhagen, Denmark

Value in Health, Volume 26, Issue 11, S2 (December 2023)

Code

MT73

Topic

Clinical Outcomes, Medical Technologies, Organizational Practices, Study Approaches

Topic Subcategory

Comparative Effectiveness or Efficacy, Industry, Literature Review & Synthesis, Medical Devices

Disease

Diabetes/Endocrine/Metabolic Disorders (including obesity), Medical Devices

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