Health-Related Quality of Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis

Author(s)

Bolbocean C1, Petrou S2
1University of Oxford, Oxford, , UK, 2University of Oxford, Oxford, UK

Presentation Documents

OBJECTIVES: Assessment of health-related quality of life (HRQoL) for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on HRQoL in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based HRQoL outcomes in early adulthood. Individual participant data (IPD) were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ consortium.

METHODS: The combined dataset included over 2,100 adult VP/VLBW survivors ranging in age from 18 to 29 years. Data were analyzed using generalized linear mixed models in a one-step approach using fixed and random effects models. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Main outcomes were preference-based HRQoL measures in early adulthood, including the Health Utilities Index Mark 3 (HUI3) and the Short Form 6D (SF-6D), were harmonized across the five cohorts.

RESULTS: VP/VLBW status was associated with a clinically significant decrease in HUI3 multi-attribute utility score of -0.06 (95% CI: -0.08, -0.04); this was not replicated for the SF-6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional, pain or social functioning. VP/VLBW status is associated with lower overall HRQoL in early adulthood, particularly in terms of physical and cognitive functioning.

CONCLUSIONS: VP/VLBW status is predominantly associated with decrements in physical and cognitive aspects of HRQoL during adulthood. Studies that estimate the effects of VP/VLBW status on HRQoL outcomes in mid and late adulthood are needed.

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)

Code

PCR190

Topic

Patient-Centered Research

Topic Subcategory

Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes

Disease

SDC: Pediatrics

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