Impact of COVID-19 Pandemic on HPV Vaccine Initiation Rates in Adolescent Girls: Projected Time to Reverse Dose Deficits in France
Author(s)
Mamane C1, Farge G2, Bensimon L3, Morais E4, Saxena K4
1MSD France, Puteaux, 92, France, 2MSD France, Asnières-sur-Seine, 92, France, 3MSD France, Puteaux, France, 4Merck & Co. Inc, Rahway, NJ, USA
OBJECTIVES:
The COVID-19 pandemic has led to significant disruption in health care including the administration of recommended HPV vaccines in France. According to national claims database, HPV vaccine initiation rates have markedly decreased between 2019 and 2020 due to lockdown (-5% in girls aged 11-14 and -15% for girls aged 15-19). The objective of this study is to estimate the time required to reach pre-pandemic levels of initiation rates.METHODS:
A prediction model was adapted to France. Reductions in HPV vaccine initiation doses administered to girls aged 11-14 and 15-19 were quantified using French National claims database. The model used the observed number of first doses administered in 2019 and 2020 and estimated the accumulated deficit at start of catch-up period (assumed to be in September 2022 as the end of COVID impact) and time-to-reverse deficit to return on pre-COVID-19 trends.RESULTS:
The accumulated deficit of initiations rates at start of catch-up period, was projected to be -10% (21 206 missed doses) and -39,8% (47 334 missed doses) for 11-14 and 15-19-years old girls, respectively. This projected deficit is expected to be cleared in 2023 and 2026 in girls aged 11-14 and 15-19, respectively, depending on an annual catch-up rate of 10%. A 5% annual catch up rate scenario leads to late 2024 and 2030, respectively.CONCLUSIONS:
The recovery to pre-pandemic HPV vaccine initiation trends will require a sustained increase in vaccination over the following years. The extension of vaccination competencies to pharmacists can ease access to vaccination and help to recover the accumulated deficit. Additionally, extending recommendations beyond the age of 19 would allow to catch up on missed vaccinations. Of note, this study considered the COVID-19 impact based on year 2020 but this impact persisted in 2021 and early 2022; the estimation of the full COVID impact requires an additional follow up.Conference/Value in Health Info
2022-11, ISPOR Europe 2022, Vienna, Austria
Value in Health, Volume 25, Issue 12S (December 2022)
Code
EPH109
Topic
Epidemiology & Public Health, Methodological & Statistical Research
Topic Subcategory
Public Health
Disease
STA: Vaccines