Censoring in the Time Trade-Off Valuation of Worse-Than-Dead EQ-5D-5L Health States: Can a Willingness-to-Accept Question be the Solution?

Author(s)

Liao M1, Rand K2, Yang Z3, Hsu CN4, Lin HW5, Luo N1
1National University of Singapore, Singapore, Singapore, 2Akershus University Hospital, Lørenskog, Norway, 3Guizhou Medical University, Guiyang, China, 4Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 5China Medical University, Taichung City, Taiwan

OBJECTIVES: The left censoring design of the composite time trade-off (cTTO) tasks leads to excessive amount of -1 values in some EQ-5D-5L valuation studies. This study aimed to investigate whether the elicitation of values less than -1 can solve this issue and improve the estimation of EQ-5D-5L values.

METHODS: At the end of each cTTO task in the Taiwanese EQ-5D-5L valuation study, if the value of the health state was indicated to be less than -1, a willingness-to-accept question eliciting the indifference point between a hypothetical life (i.e. x number of years in full health followed by 10 years in the health state) and immediate death was used to estimate its uncensored value. We compared the statistical characteristics of the censored and uncensored values.

RESULTS: Four hundred and twenty-nine of 1,000 respondents were offered the willingness-to-accept question in a total of 1,071 cTTO tasks. In 79.55% of those tasks, indifference was not reached. Spearman’s correlation with misery index was -0.41 and -0.40 for negative uncensored and censored values, respectively. The logical inconsistency rates of the uncensored and censored values were 0.88% vs. 0.29%, respectively. Modelling of the uncensored values resulted in coefficients with greater uncertainty and much lower predictions.

CONCLUSIONS: The elicitation of values less than -1 by granting more time to trade seems not a promising solution to the value censoring of the cTTO tasks. Other strategies for valuation of very poor health states should be explored.

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)

Code

PCR125

Topic

Patient-Centered Research

Topic Subcategory

Health State Utilities, Instrument Development, Validation, & Translation

Disease

No Additional Disease & Conditions/Specialized Treatment Areas

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