Factors Influencing Intent to Vaccinate Against Respiratory Syncytial Virus (RSV) Among Older Adults in Australia, Hong Kong, Japan, New Zealand, South Korea, Singapore, and Taiwan
Author(s)
Lawrence Vandervoort, Master’s in Public Health (MPH)1, Amanda Woo, PhD1, Neeyor Bose, PhD1, Maria Choufany, PhD2, Aruni K. Seneviratna, Master of Public Health (MPH)3, Yu-Fan Ho, MPH4, Leila Alaoui Sosse, Masters2.
1Oracle Life Sciences, Singapore, Singapore, 2Oracle Life Sciences, Paris, France, 3GlaxoSmithKline, Singapore, Singapore, 4Real World Evidence & Health Outcomes, GlaxoSmithKline, Singapore, Singapore.
1Oracle Life Sciences, Singapore, Singapore, 2Oracle Life Sciences, Paris, France, 3GlaxoSmithKline, Singapore, Singapore, 4Real World Evidence & Health Outcomes, GlaxoSmithKline, Singapore, Singapore.
Presentation Documents
OBJECTIVES: Respiratory Syncytial Virus (RSV) is a leading cause of severe respiratory illnesses among infants and older adults. With recent approvals of RSV vaccines for older adults, this study aims to understand the factors influencing vaccination intention to optimize RSV vaccine uptake.
METHODS: This cross-sectional, survey-based study recruited 3,430 older adults aged ≥50 years from Australia, Hong Kong, Japan, New Zealand, South Korea, Singapore, and Taiwan. Respondents were grouped into general population (N=1,807) and high-risk (N=1,623, based on respiratory conditions, diabetes, cardiovascular conditions, chronic kidney disease or liver disease) and further sub-grouped by age (50-59, 60-74, and ≥75 years). Logistic regression models examined sociodemographic (e.g., age, gender, education) and health (e.g., frailty) factors, and attitudes towards RSV (e.g., immunity preference, concerns over respiratory infections [RI], convenience, affordability) as predictors of vaccination intent.
RESULTS: Multivariate analysis revealed that convenient access to vaccination services (odds-ratio [OR]: 1.89-3.06) drove vaccine intent across all age groups within the general population. Among high-risk individuals, strong concern for RI (OR: 2.42-3.74) and vaccine affordability (1.76-1.82) were key facilitators. Conversely, respondents with preference for natural immunity were less likely to get vaccinated against RSV in both general (OR: 0.29-0.47) and high-risk populations (OR: 0.39-0.59). Univariate analyses spotlighted additional factors such as frailty (OR: 1.53-2.23), being partially/fully dependent (OR: 2.90-3.90) and having high concerns for RI (OR: 2.57-3.17) among the general population aged 50-59 and 60-74 years; convenience (OR: 1.68-2.09) was also a factor among the high-risk individuals, though not independently sustained in the multivariate models.
CONCLUSIONS: This study revealed accessibility to vaccination centers, affordability, and concerns of RI as facilitators for RSV vaccination amongst older adults aged ≥50 years while preference for natural immunity is a barrier to RSV vaccine uptake. Vaccination campaigns tailored to these insights can optimize strategies for promoting RSV vaccination among older adults.
METHODS: This cross-sectional, survey-based study recruited 3,430 older adults aged ≥50 years from Australia, Hong Kong, Japan, New Zealand, South Korea, Singapore, and Taiwan. Respondents were grouped into general population (N=1,807) and high-risk (N=1,623, based on respiratory conditions, diabetes, cardiovascular conditions, chronic kidney disease or liver disease) and further sub-grouped by age (50-59, 60-74, and ≥75 years). Logistic regression models examined sociodemographic (e.g., age, gender, education) and health (e.g., frailty) factors, and attitudes towards RSV (e.g., immunity preference, concerns over respiratory infections [RI], convenience, affordability) as predictors of vaccination intent.
RESULTS: Multivariate analysis revealed that convenient access to vaccination services (odds-ratio [OR]: 1.89-3.06) drove vaccine intent across all age groups within the general population. Among high-risk individuals, strong concern for RI (OR: 2.42-3.74) and vaccine affordability (1.76-1.82) were key facilitators. Conversely, respondents with preference for natural immunity were less likely to get vaccinated against RSV in both general (OR: 0.29-0.47) and high-risk populations (OR: 0.39-0.59). Univariate analyses spotlighted additional factors such as frailty (OR: 1.53-2.23), being partially/fully dependent (OR: 2.90-3.90) and having high concerns for RI (OR: 2.57-3.17) among the general population aged 50-59 and 60-74 years; convenience (OR: 1.68-2.09) was also a factor among the high-risk individuals, though not independently sustained in the multivariate models.
CONCLUSIONS: This study revealed accessibility to vaccination centers, affordability, and concerns of RI as facilitators for RSV vaccination amongst older adults aged ≥50 years while preference for natural immunity is a barrier to RSV vaccine uptake. Vaccination campaigns tailored to these insights can optimize strategies for promoting RSV vaccination among older adults.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
PCR98
Topic
Patient-Centered Research
Topic Subcategory
Adherence, Persistence, & Compliance, Patient Behavior and Incentives, Patient Engagement
Disease
Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory), Vaccines