Abstract

Objectives

We aim to raise awareness of potential applications of synthetic data within the health economics and outcomes research (HEOR) community.

Methods

We provide a concise overview of synthetic data, including data generation and types. We then discuss 3 major data-associated challenges and how synthetic data may be used to address them. Finally, we discuss data utility, privacy protection, potential concerns of its applicability, and future research direction.

Results

The use of synthetic data is an alternative privacy protection technique to enhance data availability, strengthen the robustness of findings for underrepresented populations, and alleviate data insufficiency issues in rare disease research. More studies are needed to explore synthetic data use and address data challenges in HEOR studies. Furthermore, the development of an evaluation framework is encouraged to better support the integration of synthetic data into the HEOR field.

Conclusions

Synthetic data provide a unique opportunity to overcome data-related challenges in HEOR.