Event

Apply benchmarking and trial emulation to strengthen real-world evidence

This course explores how benchmarking against reference trials and trial emulation can improve the validity of real-world evidence (RWE) studies. Through current frameworks, regulatory case studies, and an extended example, participants will learn how study design influences the interpretation and credibility of RWE.

Technical topics include:

• Principles of decision-grade real-world evidence
• Current RWE frameworks and regulatory guidance
• Benchmarking and trial emulation methods
• Design considerations for indication expansion studies

This course includes tools and concepts that can be immediately applied, including:

• Case studies demonstrating RWE in regulatory and HTA decision-making
• An interactive extended example exploring trial design choices
• Practical approaches for evaluating study validity and interpretability
• Strategies for strengthening RWE to support healthcare decision-making

Participants will gain the knowledge and skills to critically assess RWE study design and understand how methodological decisions influence the reliability and interpretation of study findings.

PREREQUISITE: Students are expected to be familiar with relevant concepts and methodologies for analyzing real-world data.

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*Conference attendance is not required to attend an ISPOR Short Course. Separate registration is required for conference attendees.

Visit the ISPOR Europe 2026 Program page to view all short courses offered.

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