HEOR News
FDA Reminds Medical Companies and Researchers of Trial Results Transparency Requirements (FDA)
The US Food and Drug Administration has reminded more than 2200 medical product manufacturers and researchers to disclose clinical trial results—including unfavorable results—as required by law. According to an internal analysis, 29.6% of studies that are highly likely to fall under mandatory reporting requirements have no results submitted to the online database. Read more.
Proposed 2027 US Budget Cuts $4.3 Billion for Global Health, Prioritizes Bilateral MOUs (Health Policy Watch)
US President Donald Trump’s proposed 2027 budget will eliminate $4.3 billion for global health, including all funding for the Pan-American Health Organization and disease-specific State Department accounts like the US President’s Emergency Plan for AIDS Relief. The budget calls for global health assistance to be contingent on bilateral memorandums of understanding (MOUs) with individual countries. Read more.
Genetic Variants May Help Predict Weight Loss and Side Effects Associated With GLP1 Medications (Nature)
Genetic variants are associated with outcomes and adverse events in people taking glucagon-like peptide 1 (GLP1) receptor agonists for weight management, according to an analysis from the 23andMe Research Institute. The study identified 1 variant associated with increased weight loss efficacy and 2 variants associated with drug-related nausea or vomiting. Read more.
Custom Offloading Footwear Cost-Effectively Help Prevent Diabetic Foot Ulcer Recurrence (Diabetologia)
Custom footwear designed to offload high pressure areas of the foot is cost-effective with high probability for helping to prevent foot ulcer recurrence in patients with diabetes, according to research from The Netherlands. The maximum probability for cost-effectiveness was 0.81 overall and 0.95 in the subgroup of patients who wore the footwear as prescribed. Read more.
Model Finds 10-Year Outcomes Favor Stool-Based Colorectal Cancer Screening Over Colonoscopy (JME)
Cumulative screening effectiveness over 10 years is greater for stool-based colorectal cancer screening every 3 years than 1 colonoscopy, according to a model-based evaluation that incorporated real-world adherence data. Next-generation multitarget stool DNA testing was associated with greater colorectal cancer mortality reduction and 62% more life-years gained compared with colonoscopy. Read more.
Cost-Effectiveness Study Supports Food Fortification to Address Global Dietary Deficits (The Lancet Global Health)
Large-scale food fortification (adding micronutrients to commonly consumed foods during processing) is a cost-effective intervention that greatly reduces nutritional deficiencies, according to an analysis that integrated modeled dietary data from the Global Dietary Database and fortification program parameters from the Global Fortification Data Exchange. Read more.
Real-World Evidence Details Extent of Pandemic Blood Pressure Control Disruption (JAHA)
Blood pressure control rates were disrupted during the COVID-19 pandemic among patients with hypertension and had not fully rebounded by the end of 2022—a deficit that could adversely affect cardiovascular outcomes, according to a study that analyzed electronic health record data from the National Patient-Centered Clinical Research Network. Read more.
Modeling Data Inform Swedish Decision to Implement National Chickenpox Vaccination (Acta Paediatrica)
Sweden’s new national program for varicella (chickenpox) vaccination is predicted to result in both health gains and reduced costs from a societal perspective, according to a modeling study by the Public Health Agency of Sweden that informed the government’s decision to approve the program. The predicted cost savings were primarily due to a reduction in caregiver productivity loss. Read more.
Black Adults in Canada Report More Cost-Related Prescription Nonadherence Than White Adults (CMAJ)
Black adults in Canada are more likely than White adults to cite cost concerns as a reason for declining to fill a prescription or skipping doses, according to an analysis of person-level microdata from 5 cycles of the Canadian Community Health Survey. Having insurance coverage significantly reduced the rate of cost-related nonadherence among both Black and White adults. Read more.
Cost-Effectiveness Drives Practice for Preventing Hospital-Acquired Infection (JAMA Network Open)
Cost-effectiveness consistently drives selection of infection prevention and control practices against hospital acquired infection, according to a survey conducted by researchers from Singapore. The survey, which included 256 health professionals from 6 global regions, found that implementation duration was the least important attribute across most regions. Read more.
