Social determinants of health (SDOH) are increasingly being recognized as important contributors to healthcare costs and outcomes that must be recognized and addressed. Drawing upon the public health discipline, the first speaker will present a conceptual framework of SDOH constructs and data sources commonly used to analyze them. Speaker 2 will discuss methods currently being applied to understanding and accounting for the relationship between SDOH and health outcomes in real world data. The speakers will be followed by a discussant who will reflect upon lessons learned and explore future directions for furthering HEOR methods in this area.