The COVID-19 pandemic has had a profound impact on Latin America and is accelerating widespread changes in the region’s highly fragmented healthcare landscape. Innovative, agile and timely HTA processes will be instrumental to meet the needs of rapidly changing systems and technological innovation. Through practical cases shared by expert panelists, this session will cover key areas where HTA is evolving for the region, including with novel HTA processes for high cost therapies including gene therapies, the deployment of HTA in hospital and other care settings, and how digital transformation is bringing real world data (RWD) into greater prominence into decision-making.