OBJECTIVES: To explore patient reported outcomes (PROs) of breast cancer, with a sub analysis in metastatic stage METHODS: A systematic review of literature was performed in Pubmed in order to find patient reported outcomes in initial and metastatic stages of patients with breast cancer. RESULTS: were the most frequent PROs reported from breast cancer patients. Observed factors associated with a better status of quality of life were: Higher educational level, higher income, work stability, stable partnership, emotional support and shared decision making with clinicians. Observed factors associated with a worse status of quality of life were: Isolation, paternalism form clinicians at time of decision making, diagnosis of disease at younger age. In metastatic subgroup analysis, the most frequent PROs were hot flushes, weight gain, loss of appetite, fatigue, impaired libido, somnolence, anxiety and vaginal dryness. In advances stages also were observed higher out of pocket expenses in disease management due to a higher usage of health services, specifically in emergency services. CONCLUSIONS: The exploration of additional dimensions of patients’ consequences in breast cancer delivers a broader overview of what else matters to patients and should be taken into account by decision bodies and clinicians alongside survival and progression of disease.