RISPERIDONE LONG ACTING INJECTION (RLAI) IN THE TREATMENT OF EARLY VERSUS LATE DIAGNOSIS PATIENTS WITH SCHIZOPHRENIA- INTERIM RESULTS FROM OBSERVATIONAL STUDIES CONDUCTED IN SPAIN, AUSTRALIA AND BELGIUM
Author(s)
Annette Lam, MHE, Manager, Health Economics and Pricing1, J M Olivares, MD, PhD, DR2, T J R Lambert, Bsc, MBBS, PhD, Associate Professor3, J Peuskens, MD, PhD, Professor4, Sue Caleo, MCom, Director of Health Economics5, Michael Povey, PhD, Senior Biostatistician61Johnson and Johnson Pharmaceutical Services, Toronto, ON, Canada; 2 Servicio de Psiquiatria Hospital, Vigo, Spain; 3 The University of Melbourne, Melbourne, Victoria, Australia; 4 Universitair Psychiatrisch Centrum, KUL Leuven, Leuven, Belgium; 5 Janssen Pharmaceutica N.V, Beerse, Belgium; 6 SGS Life Science Services Belgium, Wavre, Belgium
OBJECTIVES: To compare 12-month psychiatric-related hospitalization pre and post-RLAI therapy and clinical outcomes in early (<5-years) versus late (°Ý5-years) diagnosis outpatients with schizophrenia from e-STAR in Spain (SP), Australia (AU), and Belgium (BE). METHODS: E-STAR is a secure, web-based, international, long-term observational study of patients with schizophrenia who commence RLAI treatment. Data are collected both retrospectively and prospectively and include hospitalisations and clinical outcomes that were evaluated using the Clinical Global Impression Severity Scale (CGI-S) and Global Assessment of Functioning Scale (GAF). RESULTS: Overall, 714 patients (SP=393, AU=249, BE=72) were included. Twenty-two percent were classified as early diagnosis. Average time since diagnosis was 2 and 15.9 years in the early and late diagnosis group, respectively. Patients in the early diagnosis group were significantly younger than those in the late diagnosis group (32.2 vs. 41.7, p<0.001). Both groups experienced a significant decrease in the number of hospitalizations per patient in the 12-month post versus the 12-month pre-RLAI period (early=0.77 to 0.36, p<0.001; late=0.54 to 0.43, p=0.004). Reduction in hospitalization rates per patient from the pre and post-RLAI period was significantly greater in the early diagnosis group (early=-0.4, late=-0.11, p=0.006). The average length of stay (in days) decreased for both groups but it was only statistically significant in the early diagnosis group (early=21.2 to 12.4, p=0.041; late=15.6 to13.6, p=0.40). Both groups experienced significant improvements in GAF and CGI-S scores. However, the early diagnosis group experienced greater improvements in GAF and significantly greater improvements in CGI (GAF: early=+14.1, late=+12.5, p=0.30; CGI: early=-1.04, late=-0.76, p=0.017). CONCLUSION: This interim analysis suggests that treatment with RLAI result in better outcomes in patients with schizophrenia who have been diagnosed for less than five-years than those diagnosed for five or more years.
Conference/Value in Health Info
2007-05, ISPOR 2007, Arlington, VA, USA
Value in Health, Vol. 10, No.3 (May/June 2007)
Code
PMH41
Topic
Study Approaches
Topic Subcategory
Registries
Disease
Mental Health