MENTAL AND PHYSICAL FUNCTIONING REDUCED AMONG PATIENTS WITH FREQUENT ATYPICAL GERD SYMPTOMS
Author(s)
Bonnie B Dean, PhD, MPH, Principal Investigator1, Daniel Aguilar, MPH, Research Associate1, James E McGuigan, MD, Professor2, William C Orr, PhD, Clinical Professor of Medicine3, Ronnie Fass, MD, FACP, FACG, Professor of Medicine4, Lawrence F Johnson, MD, Professor of Medicine5, Diana Morgenstern, MD, Associate Director, Clinical Affairs6, Robert W Dubois, MD, PhD, Senior Vice President11Cerner LifeSciences, Beverly Hills, CA, USA; 2 University of Florida, Gainesville, FL, USA; 3 Oklahoma University Health Sciences Center, Oklahoma City, OK, USA; 4 University of Arizona, Tucson, AZ, USA; 5 University of Alabama at Birmingham, Birmingham, AL, USA; 6 Wyeth Pharmaceuticals, Collegeville, PA, USA
OBJECTIVES: Assess health-related quality of life (HRQOL) among patients with gastroesophageal reflux disease (GERD) who have frequent symptoms considered atypical for GERD. METHODS: A sample of US adults participated in a web survey including the GERD Symptom & Medication Questionnaire (GERD-SMQ), a validated GERD screener. Frequency of atypical symptoms (globus, sinusitis, dry coughing, throat clearing, sore throat, snoring, wheezing, choking, non-cardiac chest pain, and hoarseness) during the previous 3 months were assessed. Frequent symptoms were defined as = 2 days/nights per week with each symptom. SF-36 Mental Component Summary (MCS) and Physical Component Summary (PCS) scores were calculated and mean differences were compared for respondents with GERD and atypical symptoms vs. those with GERD but without atypical symptoms. Bonferroni correction was used to adjust for multiple comparisons testing. Lower scores signified worse HRQOL; differences of 2 or more points are generally considered clinically significant. RESULTS: 2,805 of 18,213 invited to participate responded. 2,603 satisfied the study criteria; 701 were individuals with GERD. Overall, 74% and 66% of individuals with GERD reported at least one nighttime or daytime atypical symptom, respectively. Mean MCS and PCS scores among GERD cases were significantly lower among those with vs. without each nighttime atypical symptom (P<0.007 for all nighttime atypical symptoms). Similar reductions in mean MCS and PCS were seen among GERD cases with daytime atypical symptoms when compared to those without each daytime symptom (P<0.0056 for all). Mean MCS and PCS scores were 4-10 points lower among GERD cases with atypical symptoms compared with GERD cases without atypical symptoms. CONCLUSION: Nighttime and daytime atypical symptoms were associated with significantly lower HRQOL scores. Among GERD patients, there may be an incremental negative impact of atypical symptoms on mental and physical functioning. Clinicians should determine the presence of atypical symptoms in an effort to improve HRQOL in patients with GERD.
Conference/Value in Health Info
2007-05, ISPOR 2007, Arlington, VA, USA
Value in Health, Vol. 10, No.3 (May/June 2007)
Code
PGI15
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Gastrointestinal Disorders
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