OBJECTIVES: To measure and compare generic and disease-specific HRQoL in stroke survivors one to two years post hospital discharge. METHODS: The SF-36 and the Stroke Impact Scale (SIS) were administered to 33 stroke survivors. The standard gamble method was used to elicit utilities regarding stroke health states. RESULTS: Of the 33 patients, 79% were male, 67% had mild stroke, 24% had moderate stroke, and 9% had severe stroke; mean age was 66.9. Study participants scored significantly lower (p<0.05) than the general population on seven of the eight multi-item scales of the SF-36: Physical Functioning, Role-Physical, General Health, Vitality, Social Functioning, Role-Emotional, and Mental Health. Participants scored significantly lower (p<0.001) than the general population on both physical and mental health component summary measures. Using the SIS, participants had a mean score of 57.23 on the physical summary score. On the four component scales of the physical summary score, participants had mean scores of: 44.14 on Strength, 50.31 on Hand Strength, 65.93 on Mobility, and 71.26 on Activities of Daily Living (ADL). Participants had mean scores of 79.55 on Memory, 85.91 on Communication, 73.18 on Emotional, and 57.68 on Social Participation. SIS Physical was significantly correlated (p<0.05) with both SF-36 physical measures. Both the SF-36 mental component scores and Mental Health domain measure were significantly correlated with the SIS measures of ADL, Memory, Communication, Emotional, and Social Participation (p<0.05). The mean standard gamble utility score for all participants was 83.2. CONCLUSION: Stroke survivors one to two years post stroke had significantly lower scores than the general population on most of the SF-36 health domains with the exception of bodily pain. Positive correlations with major domains of the disease-specific SIS indicate that the SF-36 was sensitive to stroke health states. Further research with a larger sample size and severity sub-group comparisons is ongoing.