HEALTH STATUS VALUES (UTILITIES) FOR THE SWEDISH POPULATION- A MODEL BASED ON THE EQ-5D ASSESSMENT OF ACTUAL HEALTH STATE, USING JACKKNIFE METHOD AND MULTIPLE REGRESSION ANALYSIS
Author(s)
Jonsson B1, Koltowska-Haggstrom M2, Isacson D3, Bingefors K(31 Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; 2 Pfizer Health AB, Stockholm, Sweden; 3 Department of Pharmacy, Uppsala University, Uppsala, Sweden
OBJECTIVE: To derive health status values (utilities) for the Swedish population. METHODS: EQ-5D data were collected through a mailing survey to a random sample (n=2990) of the Swedish population (response rate 65%: complete data on 1741 (49.4% males; mean age 48.4). The model was estimated using the Jackknife method and multiple regression analysis. The full sample was randomly divided into 10 parts of approximately the same size. As a first step, regression analysis in the full sample was performed, where VAS assessment (0-100) of actual health state constituted the dependent variable and dichotomized (some problem/considerable problem) answers on the five dimensions the independent. After excluding outliers, (standardized [z-] residuals < –2.5 or > 2.5), ten pairs of analyses were performed, excluding one part of the sample at the time. From the first analysis in each pair, outliers were excluded and the second analysis was performed. The coefficients gained in the second analysis were used to calculate Jackknife estimates of “true” coefficients. RESULTS: The model estimated constant of 89.7 and coefficients for each dimension assessed as having “some problem” (self care:-15.89; mobility:-10.30; usual activities:-9.52; depression:-7.87; pain/discomfort:-7.49) and for having “considerable problem” with pain/discomfort:-6.00; usual activities:-8.09; depression:-33.66 and on any of dimensions:-20.18. Interactions did not increase explanatory value of the analysis. CONCLUSIONS: Based on this model, the most important determinant of health status value (utility) for the Swedish population is depression, followed by problems with mobility and self-care. Pain/discomfort is the least important, regardless of the magnitude of the problems were assessed.
Conference/Value in Health Info
2005-05, ISPOR 2005, Washington, DC, USA
Value in Health, Vol. 8, No. 3 (May/June 2005)
Code
PEN3
Topic
Methodological & Statistical Research, Patient-Centered Research
Topic Subcategory
Modeling and simulation, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Diabetes/Endocrine/Metabolic Disorders