OBJECTIVES: To develop a patient-reported outcomes data collection system using the internet or the telephone for migraine patients being treated with Relpax (eletriptan HBr). METHODS: Physicians provided medication and study information to eligible migraine patients in their practice willing to participate. Patients were able to access the data collection system (The Relpax Challenge), either via the Internet or an interactive voice response system (IVR). Patient kits contained preprinted ID numbers that mapped them to their physicians. Upon enrolling, migraineurs answered a baseline survey of demographic information, migraine experience and associated health care utilization, and a prior migraine medication satisfaction survey. Following the baseline survey, patients were then asked to rate their satisfaction to treatment for three subsequent Relpax treated migraine attacks. Data was collected over an SSL protected website and stored in a SQL server database. The website was developed using Macromedia and ensured a user-friendly environment for data entry. The IVR also reposited data into the same data warehouse. RESULTS: Currently 3604 registered patients have completed questionnaires for 5837 Relpax treated attacks. The majority of the respondents were female (87.53%) with an average age of 37.5 years. Forty-four percent completed data on all three attacks, of which 93.1% indicated that they would take Relpax again. Migraineurs were satisfied (four or five on a five point scale) with their relief of pain (70.20%), speed of relief (60.10%), relief of nausea (50.91%), relief of sensitivity to light (58.10%), relief of sensitivity to sound (57.29%) and their ability to return to their day (57.29%). CONCLUSIONS: Utilizing this technology, we have created a reliable and easy-to-use internet and phone based system for collecting patient reported outcomes. Satisfaction with Relpax treatment as well as other treatment outcomes were consistent with the results observed in the Relpax clinical trials.