ORGANIZATION: Medicare Advantage – Prescription Drug Program. PROBLEM OR ISSUE ADDRESSED: Medicare beneficiaries with Part-D coverage were consistently reaching their gap in coverage early in the plan year resulting in poor medication adherence, persistence and treatment outcomes. GOAL: The organization hoped to improve the cost-effectiveness of the drug selection choices made by the member and physician. The organization encouraged its members to utilize lower cost generic medications to help lower costs and avoid their coverage gap. OUTCOMES ITEMS USED IN THE DECISION: Adherence and persistence data and evidence from other pharmacy-based programs extracted from the literature was used to determine that the main outcome measure objectives were to be improved generic utilization, no decrease in essential maintenance medications, and decreased gross costs per member per month. IMPLEMENTATON STRATEGY: An internet-based pharmacy therapy quality assurance system was built to identify members that were expected to reach their coverage gap within the plan year. The members' profiles were reviewed by the staff pharmacist for lower cost therapeutic alternative generic medications. The members were sent a letter (and possibly their physician) about available drug alternatives. RESULTS: •16.3% increased generic utilization vs. 6.8% increase in control group •2.9% decreased essential medication PMPM vs. 3.8% decrease in control group •4.5% decrease in gross cost PMPM vs. 5.0% increase in control group. LESSONS LEARNED: That a pharmacist-driven, internet-based intervention can improve cost-effective drug therapy. However, the amount of efficient spending is dependent upon the efficiency in which the program is delivered. Greater efficiencies will need to be considered for broader population exposure.