OBJECTIVES: Establish the impact that present chemotherapy management is having on the quality of life (qol) of patients being treated at the Prince Charles Hospital; Allow comparison of the effect on the patients qol between established treatment modalities; Allow comparison of the effects on patients qol between established and future trial treatment protocols. We report the interim findings of this ongoing quality of life study. METHODS: all patients referred for chemotherapy management of their non-small cell lung cancer (NSCLC) were asked to participate. The EORTC QLQ 30 and LC 13 were used to assess patients qol when disease restaging tests were conducted. Data was entered into an access database that allowed comparison. Protocols used were CIV, CV- adjuvant-neoadjuvant setting. CG and single agent Gemcitabine 1000mg/m2 on days 1, 8, 15, in the palliative setting. RESULTS: Patients ages ranged 39 to 73 yrs, average age 53 yr, median, 51, mode 47years. The sample consisted of 3 females & 12 males, 6 patients are not reported, 3 neoadjuvant had progressive disease after two cycles and were not followed, 3 palliative patients died after one cycle of treatment. Of the 21 patients treated 15 (71%) had improved Quality of Life Quality of Life scores paralleled other measures of assessment. Scans shows response to single agent Gemzar in the palliative setting and response to CIV in the neoadjuvant setting. CONCLUSION: we demonstrated 71% of our patients had qol improvements. Management of patients with NSCLC should consider chemotherapy. FUTURE DIRECTION: An outcomes study is being conducted at two campuses in Brisbane. This study seeks to include all newly diagnosed lung cancer patients and follow their progress through their disease using clinical Quality of Life and economic criteria to determine outcome. Comparison between treatment and within treatment arms will be compared.