OBJECTIVES: To measure the willingness-to-pay of patients who suffer from benign and intense chronic pain and to investigate the relationship with the social and demographic characteristics of the sample and the stated and perceived quality of life. METHODS: Data from a research on a sample of 205 and 158 patients suffering from intense and chronic pain will be discussed, as in the questionnaire it was asked how much every patient would be disposed to pay to eliminate pain. The question previewed an alternative answer between 4 possibilities that represent a range of values that were defined a priori. Contents: To estimate in a critical way the use of the WTP method cost effectiveness analyses. In this case the WTP is used as an indicator of the potential question of the patients for a greater treatment of pain. Results about WTP and the relations between the social and demographic features will be discussed. WTP will also be associate to the expectations on the treatment of pain and the quality of life level and expected utility, obtained by the SF-36 and EQ-5D questionnaires, before the start of treatments and after the check of therapy. RESULTS: The analysis has allowed to quantify in €126,53 the willingness to pay in order to eliminate the intense pain in 24 hours and in €236,74 the mean of the willingness to pay in order to eliminate the chronic pain in 30days. CONCLUSION: Combined analyses of the WTP and the quality of life (Eq-5d) has shown interesting relations between the gravity of painful pathology and the willingness to pay in order to eliminate it. Meaningful relations have recorded also between the WTP and the different kinds of perceived pain and expectation in the treatment of pain.