OBJECTIVES: Diabetes Mellitus (DM) is a major health care issue potentially causing prolonged ill health and premature death. Good adherence to prescribed diabetic regimen is important to prevent complications but it needs supports from a variety of health care professionals. This study was to explore the non-compliance profile of diabetic patients and to evaluate the clinical benefits by a pharmacist-managed diabetes clinic on the degree of glycemic control through the provision of diabetic information and the implementation of a drug compliance enhancement program for the non-compliant diabetic patients. METHODS: Patients with poor medication compliance were recruited to receive three counseling sessions carried out by a hospital pharmacist. The baseline levels of compliance and hemoglobin A1C (HbA1C) were documented. The responsibility of the pharmacist in the clinic was to educate all patients individually regarding diabetes and its complications and on the proper use of their medicines. Patients were reassessed and reinforced on their levels of compliance and medication knowledge during the subsequent visits. The primary outcome measurement was the change in HbA1C over the 12-month study period. RESULTS: Ninety-five patients were recruited during the 12-month study period with 91 patients completed the study. Improvement of HbA1C was observed as compared with the first clinic visit to the final clinic visit (7.43 "b 1.57% to 7.15 "b 1.33%, p<0.005). The mean compliance level improved significantly from 41.3% to 97.8% (p<0.005). CONCLUSION: The study suggested that pharmacist-managed compliance clinic for non-compliant diabetic patients was effective and had a clinical impact on the glycemic control of patients. Pharmacist can play an important role in implementing and monitoring diabetic therapy along with the multidisciplinary team effort in diabetes management.