OBJECTIVES: Compliance is a concern when trying to capture resource use (RU) data over a long period. An IVRS was developed to capture RU data for chronic obstructive pulmonary disease and to assess the viability of using a patient-oriented IVRS system for periodic and long-term RU data collection. This presentation will focus on results of the second objective. METHODS: This study was done over 58 weeks in parallel with a clinical trial. At the initial study visit, subjects were instructed in the use of the IVRS, provided written instructions and a Health Care Resource Use Tracking Aid(c) for each of 14 reporting periods. Subjects were instructed to record RU daily on the tracking aid and to report via the IVRS toll-free number each 30 days during the course of the study. IVRS data were accessed weekly for data monitoring. Reminders were generated to patients who did not complete a scheduled report. Two RU reporting periods extended beyond the last clinical trial visit. Subjects resided in 23 states. RESULTS: Males comprised 58% of study subjects; 55% were greater than 65 years old; and 53% resided in Southern states. All 381 IVRS users reported resource use data at least once. The average number of IVRS reports per subject was 10.5 (sd=4.5). Of those subjects who finished the trial, 89% completed at least 12, and 46% completed all 14 data reports. CONCLUSIONS: This study demonstrated that multiple data reporting via an IVRS can be used successfully for collecting long-term health care resource use data even when a substantial portion of the subjects are elderly. The IVRS developed for this study provided an optimal method for collecting detailed analyzable-ready data without adding additional visits to the trial while providing subjects a convenient and user-friendly method of reporting.