Drug-related morbidity (DRM) results in significant cost and consequence. Fifty percent or more of DRM may be preventable (PDRM). Strategies to reduce the problem of PDRM need to be identified in order to improve the quality of medication use. OBJECTIVES: (1) To determine the perceived efficacy of each of eight strategies for reducing PDRM, as expressed by physicians, and (2) whether this ranking varied depending upon physician group. METHODS: Three panels of physicians (twelve general practitioners [GPs], six geriatricians and six clinical pharmacologists) who developed and validated quality indicators of PDRM in older adults, received a follow-up mail survey to identify strategies to reduce PDRM. Each physician was asked to decide how best to reduce PDRM by choosing from eight intervention strategies for each quality indicator their group had developed. For each indicator, the physician could choose from zero, to all eight, intervention strategies. RESULTS: The most commonly chosen strategy per PDRM indicator was monitoring (72.5%) with health system management (54.6%) and patient/caregiver cooperation (52.1%) second and third, respectively. Monitoring was the most commonly chosen strategy per indicator by the GPs (81.4%) and the clinical pharmacologists (64.5%). The geriatricians chose health system management most commonly as a strategy per indicator (72.5%). Overall, an average of 3.95 intervention strategies was chosen per clinical indicator of PDRM. CONCLUSIONS: A survey of a group of clinicians revealed that monitoring is perceived to be the most important strategy to reduce PDRM among eight interventions considered. Still, it appears a combination of intervention strategies is needed to optimally reduce PDRM. These findings should serve to guide future research efforts and health policy aimed at improving the quality of medication use by minimizing PDRM in older adults.