OBJECTIVE: To calculate costs for patients with myocardial infarction (MI) in common medical practice in Russian Federation. METHODS: Data on resource use for hospital treatment of patients with acute myocardial infarction were extracted from 99 medical charts at 3 hospitals at Moscow, Tula and Vladimir. Data on resource use for out-patient follow-up for patients after acute myocardial infarction were identified according to experts’ opinion. A total of 12 experts filled in the questionnaire for identifying typical follow-up strategy for 1.5 years after MI. Direct medical costs were calculated on the basis of price-lists for medical services and median prices for drugs given in a wholesale pharmaceutical informational bulletin. RESULTS: Median cost for acute period of MI at hospital was 25,340.00 rubles ($794.36) per patient. There was no significant difference between 3 hospitals. Median total cost for follow-up period in first 6 months after MI was 28,706.63 rubles ($899.89) per patient for services and drugs mentioned by experts. Median cost for second 6 months was 11,626.71 rubles ($364.47) per patient; each 6 months after it required 10,722.73 rubles ($336.14). CONCLUSION: Costs are relatively low because of rare use of expensive technologies: only 15% of patients received thrombolytical therapy; no coronary artery bypass surgery or stent implantation were used.