OBJECTIVE: Rational administration of drugs takes into account drug price/type,pharmaceutical form, unit dose price, associating success of a treatment with a given drug or drugs with expenses related to the specific therapy. The paper is aimed at: analysis of antihypertensive therapy prescription practice along with economic parameters and analysis of consumption of antihypertensive drugs in the Clinical Center of Serbia (CCS) in accordance with the National Guide to Prevention of Ischemic Disease. In spite of the high distribution of other heart diseases in the structure of cardiovascular deaths, Serbia is, based on the WHO data, classified into the group of countries with relatively high risk of deaths associated with coronary diseases, among both males and females aged between 40 and 49 years. METHODS: The study was carried out at the CCS based on the data provided by the Pharmacy and Medical Supply. All the drugs mentioned in the analyses are registered in Serbia and the costs of the consumed drugs are reimbursed (100%) by the Republic Health Insurance Fund. The analysis includes consumption of drugs (according to groups) intended for treatment of hypertension in CCS over the six-month period. Consumption-based method is used as a quantification method. RESULTS: The patients were administered either single or combined drug antihypertensive therapy. All groups of the studied drugs were proved to lower arterial blood pressure, reduce morbidity and mortality associated with the cardiovascular and cerebrovascular diseases, which was the basic aim of the applied therapy. Diuretics and beta-blockers are most common drugs in treatment of hypertension and their efficacy and safety are best documented. CONCLUSION: Serbia needs restructuring of the health care system and introduction of non-budgetary financing, adequate validation of health care services, privatization of public sector and new legal regulations corresponding to the changed economic environment