OBJECTIVES: To describe the early development of a satisfaction questionnaire for eye drops used in ocular hypertension and glaucoma, developed in English and French simultaneously. METHODS: A conceptual model of expectation and satisfaction with eye drops was designed and used to guide patient (n=15) and clinician (n=4) interviews in French and UK English. Following review of the interview responses, versions of the questionnaire were simultaneously developed in two languages and then pilot-tested by six patients (three in France and three in the UK). RESULTS: After analysing the practitioners' and the patients' interviews, six potential domains were identified as having an impact on patients' satisfaction regarding their eye drop treatments. These domains are: 1) Patient characteristics (16 items); 2) Treatment characteristics (4 items); 3) Relationship between patient and practitioner (10 items); 4) Patients' feelings about their treatment (7 items); 5) Patients' compliance (3 items); and 6) Interaction between the patient and the treatment (six items). The questionnaire was developed using patients' verbatim comments in each language. After a cognitive debriefing performed with six patients (six French and six English), the wording and the domains of the questionnaire were confirmed in the two languages. CONCLUSION: The Eye Drops Satisfaction Questionnaire (EDSQ) is now available in French and UK English for use with patients receiving eye drops in ocular hypertension and glaucoma. Validation is currently underway to examine the psychometric properties of the EDSQ questionnaire.