The Health Assessment Questionnaire Disability Index (HAQ) has been proven to be a valid and reliable measure of daily living ability of arthritis patients. OBJECTIVE: To establish the clinically-meaningful improvements of the HAQ and its domain scores among RA patients. METHODS: Data were obtained from two 12-week randomized clinical trials among 2,252 RA flare patients. The HAQ, Patient and Physician Global Assessments (PtGA & PhGA) were administered to patients at baseline and week-12. HAQ is a 20-item instrument which contains eight categories of daily living activities. A composite score is calculated. PtGA & PhGA were measured on the following 1 to 5-point scale: very good, good, fair, poor, or very poor. Change scores were computed by subtracting patient’s baseline from week-12 follow-up scores. Responsiveness was estimated as the mean change score corresponding to each level of improvement in PtGA or PhGA. RESULTS & CONCLUSION: At week-12, the number of patients experiencing improvements in PtGA and PhGA were: 783 & 796 for one-level, 387 & 388 for two-levels, and 87 & 85 for three or more levels. The average improvement in HAQ disability index among patients experienced one, two, or three or more levels were 0.25, 0.47, 0.76 for PtGA and 0.26, 0.46, and 0.64 for PhGA. Using the change score corresponding to a one-level improvement or using the average difference of change between any two levels of improvement of PtGA or PhGA, the clinically-meaningful improvement score ranged from 0.21 to 0.26. Using similar methods, the clinically-meaningful improvement scores for the following eight categories of daily living were: dressing (0.29), eating (0.22), arising (0.35), walking (0.24), hygiene (0.15), reach (0.21), grip (0.24), and activities (0.28), respectively. “ECONOMIC & OUTCOMES ISSUES OF CANCER”