OBJECTIVES: Satisfaction with health care has been linked to positive health-related behaviors and improved efficacy of care. Among people with migraine headaches, there are unmet needs for appropriate diagnosis, medications, and care. This analysis will therefore explore whether treatment of migraines with prescription medications improves health-care satisfaction. METHODS: Data were obtained from a spring 2000 survey. A total of 21,986 (56%) questionnaires were returned from an initial mailing to 39,491 US adults whose names were purchased from a large marketing company. The 12-page survey covered a range of health topics including opinions, health history, and treatments. Respondents were asked how satisfied they were with their healthcare on a six-point scale from “strongly disagree” (1) to “strongly agree” (6). Migraine status was assessed by asking whether respondents had migraines (yes/no), if these were diagnosed by a doctor (yes/no), and if they used a prescription drug (Rx) to treat them (yes/no). Severity was self-reported as mild, moderate, or severe. RESULTS: A total of 4,069 people (19%) reported having migraines. Of those, 65% (n = 2,605) were diagnosed and 42% (n=1,090) of those reported currently using an Rx. Compared to those without migraines, people with migraines were less likely to be satisfied with their health care (59% v. 51%, p < .001). However, those treating their migraines with prescription medication were more likely to be satisfied than those who were not taking an Rx (59% v. 50%, p < .001). These bivariate associations remained after controlling for potential confounders (health-care resource use, overall physical and mental health), when comparing migraineurs to nonmigraineurs (B = -.07, p = .026) as well as diagnosed vs. undiagnosed (B = .25, p < .001) and people with at least moderately severe conditions (B = .26, p < .001). CONCLUSIONS: People who are successfully treated have higher health-care satisfaction. Physicians should therefore work with patients to find a medication that is effective for their patients’ spectrum of migraine symptoms.