OBJECTIVE: This report reviews the vaccine and immunization financing mechanisms of the SEAR countries presenting the financial analysis of immunization program in terms of 1) socioeconomic analysis of selected SEAR counties; 2) present situation of immunization analysis in SEAR; 3) vaccine and immunization financial system; 4) strategies analysis of vaccine and immunization; and 5) financing mechanisms of vaccine and immunization. METHODS: The ten SEAR countries, Bangladesh; Bhutan; DPR Korea; India; Indonesia; Maldives; Myanmar; Nepal; Sri Lanka; and Thailand, differ in terms of socioeconomic and health indicators. Nine out of 10 countries, the coverage trend is stable while India has the increasing coverage trend. The status of cold chain in most countries is inadequate. RESULTS: The problem of lack of fund and capital to invest in the NIP are commonly found among SEAR countries especially the low-income countries with a per capita GNP of less than $755 in year 2000. Immunization is a productive investment and is one of the best choices of investment among health interventions and possibly among a whole range of economic interventions as well. However, grant funds for immunization have been decreasing since the early 1990s, partly as a function of declining overseas development assistance in general and partly due to the donors themselves. Immunization programs require adequate and reliable funding to ensure continuity in services, and to fund continuous increases in coverage, quality and access to both traditional (EPI) and new vaccines. The most essential source of public fund of SEAR countries is through tax revenues (100%). CONCLUSION: Therefore, this study proposes several financing strategy and options, as a set of 5 Mechanisms namely: 1) Consensus Based Decision Mechanism; 2) Allocation Mechanisms and Levels of Funding including Regional/local Allocations Mechanisms, National Allocations Mechanisms, and International Donors Allocations Mechanism; 3) National Revolving Fund (NRF) Mechanism; 4) Global Alliance for Vaccines and Immunization (GAVI) Mechanism; and 5) Development Loan Mechanism.