OBJECTIVES: To determine the feasibility, validity and reliability of KINDL in an Asian school-based sample. Introduction: KINDL-Kid and KINDL-Kiddo have been culturally adapted and tested in a sample of diabetic and healthy children in Singapore with promising results. METHODS: Testing of KINDL was extended to a school-based sample more representative of the general children population. Methodology: Invitations for participations were sent to all schools in Singapore after permission was obtained from the Ministry of Education. Students aged 8-16 years old from participating schools were randomly selected. After the purpose of the study was explained, the questionnaires were administered and the participants were asked to complete the questionnaire without seeking their friends’ opinion. The students were asked to report if they had any of the chronic conditions such as asthma and diabetes. RESULTS: A total of 328 participants completed KINDL-Kid (mean score: 68.3±12.57%) while 1026 completed KINDL-Kiddo (mean score: 59.3±11.64%). 25 KINDL-Kid and 56 KINDL-Kiddo participants were asthmatics. Majority of participants in both groups were Chinese (KINDL-Kid: 74.1%, KINDL-Kiddo: 75.2%) and females (KINDL-Kid: 67.0%; and KINDL-Kiddo: 71.5%). The reliability coefficients (Cronbach’s alpha) ranged from 0.4040 to 0.7091 for KINDL-Kid and 0.3971 to 0.8448 for KINDL-Kiddo. The ceiling effect was significant (>5.0%) in four KINDL-Kid subscales but only one KINDL-Kiddo subscale, while significant flooring effect was observed in one subscale of both instruments. KINDL-Kiddo demonstrated discriminant validity (Healthy vs. Self-reported asthmatics: 56.6±11.92% vs. 51.3±13.21%, p<0.005) but not KINDL-Kid (65.5±12.76% vs.66.3±12.71%, p=0.768). CONCLUSION: The scale reliability obtained suggested a need to re-evaluate the factor structures of KINDL. A factor analysis may be warranted before KINDL is used in Singapore on a large scale.