OBJECTIVE: Skin diseases have a strong impact on the physical and mental well-being of the patient. This is confirmed by the large number of quality of life studies that exist. It is clear that dermatological diseases affect not only the life of the patient but also that of his/her partner and family. The Avène Dermatological Hydrotherapy Center, welcomes over 2500 patients a year suffering from skin diseases. The objective of the study is to demonstrate the relevance of the long-term effects of hydrotherapy treatments on patients Quality of Life. METHOD: A specific scale (DLQI Dermatology Life Quality Index) is completed by each patient at their arrival at the Avène Dermatological Hydrotherapy Center (inclusion), at the end of hydrotherapy cares (three weeks), and six months after the hydrotherapy cares. The completed questionnaires were returned by post. RESULTS: In this first analysis, the first 200 patients suffering from the three following conditions: psoriasis, atopic dermatitis were taken into account and analyzed at inclusion and at the end of the hydrotherapy cares. The DLQI score at inclusion was 34.55% at the end of hydrotherapy treatments the DLQI score was 19.17% (p<0.00001). The first 30 patients were taken into account and analyzed at inclusion and at 6 months after the hydrotherapy cares. For these 30 patients, the DLQI score at inclusion was 32.1% (. At 6 months the DLQI score was 24,2% (p<0.02). CONCLUSION: These first results show evidence of an improvement of patient’s quality of life after 3 weeks of hydrotherapy treatments (p<0.00001). These results also demonstrate the hydrotherapy cares persistency effect as shown by the improvement of patient’s quality of life 6 months after hydrotherapy treatments (p<0.02)