OBJECTIVE: To address willingness to pay (WTP) of patients with painful-irritable bladder syndrome (PIBS) using a regression model. METHODS: A sample of 60 patients with PIBS from Seattle and Philadelphia were interviewed. The survey questionnaire contained a WTP question with 11 bids ranging from $1 to $200. Two versions of the questionnaire were administered, one for “improvement” of the condition and one for “cure”. Respondents recorded whether they would accept or reject each bid at the stated dollar value. Data about patients’ self-perceived severity, symptomatology and demographic variables such as education and income was collected. RESULTS: Results were analyzed with ordinary least square regression (OLS). The dependent variable is maximum willingness to pay (WTP) which is defined as the largest dollar value of the “yes, definitely” or “yes, probably” response to the bids. Independent variables included income, education, self-perceived severity, symptom bothersomeness, number of medical appointments for their condition in the past year and number of years with the condition. CONCLUSION: The OLS analysis produced a higher expected WTP for cure than for improvement. The R-square and F statistics for each model showed that the variables in the model strongly explain the variation of WTP at a significant level. The regression results showed that education and number of medical appointments in the past year had a positive impact on willingness to pay for improvement, while education and self-perceived severity demonstrated a positive impact on WTP for cure.