OBJECTIVE: This study was conducted to determine the influence of pharmaceutical care services on renal transplant patients systolic and diastolic blood pressures. METHODS: Renal transplant patients at the Medical College of Georgia Renal Transplant Clinic were prospectively randomized into an intervention or a control group. Patients in the intervention group received pharmaceutical care services at least once monthly which included ongoing medication reviews, with emphasis on preventing or resolving medication-related problems and providing pharmacotherapy recommendations. Patients in the control group received routine clinic services but had no clinical pharmacist interaction. At each clinic visit, all patients underwent a physical exam which included blood pressure measurements. Analysis to detect differences in baseline and quarterly systolic and diastolic blood pressures between the groups was performed. RESULTS: There were no differences in baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the groups. Patients in the intervention group (n=28) had a mean SBP/DBP change of -9 mm Hg/-2 mm Hg, -13 mm Hg/-8 mm Hg, -13 mm Hg/-10 mm Hg, and -6 mm Hg/-6 mm Hg for the first through the fourth quarters of the study, respectively. Patients in the control group (n=23) had a mean SBP/DBP change of -2 mm Hg/+1 mm Hg, +10 mm Hg/+3 mm Hg, +11 mm Hg/+1 mm Hg, and +12 mm Hg/+5 mm Hg for the first through the fourth quarters of the study, respectively. Significant differences in change scores from baseline for SBP and DBP between the intervention and control groups were observed at the second, third, and fourth quarters of the study (p<0.01). CONCLUSION: Patients who received a hypertension management program which included pharmaceutical care services had greater reductions in blood pressure than patients who did not receive these services.