OBJECTIVE: The aim of this project is to evaluate the effectiveness of a program including practice guidelines, treatment algorithms, and peer comparison feedback in changing physicians prescribing behaviors in the treatment of patients with peptic ulcer disease (PUD). METHODS: A prospective intervention with a control group was conducted to determine the impact of a PUD information dissemination program targeted towards physicians in a managed care setting. Pharmacy claims data were used to assess impact of the program on utilization of eradication therapy, long-term antisecretory utilization, and total cost of drug therapy per patient. RESULTS: Preliminary data from a 3-month follow-up period are available and indicate that utilization of eradication therapy increased significantly for physicians in the intervention group compared to physicians in the control group during the post-intervention period (p = 0.02). This increase in eradication utilization was not accompanied by a significant increase in the total cost of drug therapy per patient for the intervention group compared to the control group (p = 0.82). The results from a 9-month follow-up period will be presented. CONCLUSIONS: The main goal of the study, to increase the utilization of eradication therapy, was achieved in the 3-month follow-up period. Observable modification of physician behavior in only a three-month period is a positive finding, and may indicate an even greater impact when the program is evaluated over a longer period of time.