Peptic ulcers, erosions of the stomach lining, afflict greater than 25 million Americans. Ulcers diminish quality of life and cost nearly $6 billion dollars annually. OBJECTIVE: To decrease unnecessary medical utilization, histamine-2-blocker (H2) and proton-pump-inhibitor (PPI) utilization and improve quality of life for peptic ulcer patients by using educational intervention to increase compliance to drug regimens for H. pylori eradication. METHODS: Patients were targeted for specific antibiotic therapies via drug data and verified at first telephone contact. A questionnaire developed and validated by Lewin-TAG was used for data collection. Data were collected for a 90 day period pre/post therapy regarding hospitalizations, doctor visits, emergency room visits, lost productivity, outpatient surgeries, pharmacy utilization and medical test/procedures resulting from the disease. Quality of life questions measured how often usual activities and work productivity were reduced due to peptic ulcer disease. Patient satisfaction with the program was also measured. RESULTS: (n=1,993, response rate=94.5%) Patient compliance to drug regimen was found to be 95.7%. Hospitalizations were reduced by 73% (p<.0001), doctor visits by 49% (p<.0001). Emergency room visits were reduced by 72% (p<.0001) and outpatient surgeries by 56% (p<.0001). Finally, a decrease of 54% in H2/PPI usage (p<.0001) and a decrease of 76% in medical tests/procedures (p<.0001) were seen. Participants reported a 13% decrease in pain and symptoms (p<.005) and a 34% increase in productivity (p<.0001). Participant satisfaction rate with the program was 98.6%. CONCLUSION: The CarePatterns peptic ulcer disease program improves patients quality of life, reduces unnecessary medical and pharmacy utilization, and is cost effective.