The Asthma-specific quality of life questionnaire (AQLQ-NAA) is a 19-item questionnaire and has emphasis on restrictions in social, community and cultural activities. Three domains of the AQLQ-NAA, community and social restrictions (CSR, 10 items), psychological and impact (PIM, 4 items) and symptoms (SYM, 5 items) have been identified using principal component analysis. OBJECTIVES: The purpose of this study was to identify significant predictors of the AQLQ-NAA and each of its domains. METHODS: The AQLQ-NAA was administered to a sample of 51 adult volunteers with a diagnosis of asthma at the Albuquerque Indian Hospital and three affiliated clinics. Four forward stepwise regression models were analyzed using total AQLQ-NAA scores and each domain score separately as the criterion variable. Six predictors (emergency care visits in the past 6 months, hospitalizations in the past six months, physician visits in the past six months, corticosteroids used in the past six months, asthma medications used in the past six months, and patient gender) were used in the regression models. RESULTS: Physician visits, hospitalizations and gender were significant predictors of total AQLQ-NAA scores (F=10.493, p<0.05, Adjusted R2=0.388) and the CSR domain scores (F=10.537, p<0.05, Adjusted R2=0.389). Physician visits and hospitalizations were significant predictors of the PIM domain scores (F=13.368, p<0.05, Adjusted R2=0.355). Number of asthma medications and gender were significant predictors of the SYM domain scores (F=7.107, p<0.05, Adjusted R2=0.213). CONCLUSIONS: Based on the predictors for each of the three domains, inherent differences between the domains were observed. This study helps further establish evidence of construct validity of the AQLQ-NAA and its domains.