OBJECTIVES: A study about Chronic Noncommunicable Diseases (CND) in Colombia, identified that in 2014 more than 100,000 people died from Coronary Ischemic Disease (CID), Cardiovascular Diseases (CVD), cancer, Diabetes Mellitus (DM) and Chronic Kidney Disease (CKD). A national study reported that 37.7% of Colombian population is overweight and 18.7% are obese, it means 56.4% are excess weight. The objective of this study is to determine economic burden of diseases related to overweight and obesity in Colombia, to generate information that allows decision makers to identify economic costs of this pathology. METHODS: Through a systematic review, diseases caused by excess weight were identified and the risk of becoming ill due to excess weight was determined in every disease. Burden of CID, CVD, cancer, hypertension, DM, CKD and low back pain in Colombia was determined. Proportion attributable to exposure (excess weight) of each disease was calculated and adjusted for sex or age. Average annual cost of healthcare of each NDC produced by excess weight was identified. Absolute frequency of patients with each disease caused by excess weight was calculated. Average healthcare costs for each disease caused by excess weight was calculated. RESULTS: Diseases caused by excess weight are: esophagus cancer, colon cancer, cancer of gallbladder and bile ducts, pancreatic cancer, breast cancer, uterine cancer, ovarian cancer, kidney cancer, thyroid cancer, leukemia in adults, CID, CVD, hypertension, DM, CKD and low back pain. In 2018, in Colombia there will be 1,824,041 people with excess weigh and any of these pathologies, who got ill because of their excess weight. Annual healthcare cost of these patients to Colombian health system is €1,739,017,779. CONCLUSIONS: Healthcare costs caused by excess weight in Colombia is 23.5% of annual health budget of the country. Actions of secondary prevention of these diseases should be developed in patients with excess weight.