OBJECTIVES: Optimization of therapy and prophylaxis of generalized periodontitis (GP) and chronic gingivitis (CG) by improvement of extemporal medicines in rinse and gel forms for topical treatment.

METHODS: Pharmacoeconomic and comparative analysis of treatment schemes effectiveness for existing mechanical/instrumental therapy and modified complexes for patients with periodontal diseases with presence comorbidities before local treatment and one month after for two patient groups with GP/CG main (25 person –modified complexes) and comparison (23 person –based treatment).

RESULTS: Were developed improved extemporal medicine complexes for treatment of periodontal diseases for patients with chronic hepatitis C (HCV) and iron deficiency anemia (IDA). Effective minimum and maximum value of ingredients were analyzed and optimal proportions of ingredients were chosen. Before treatment, level of dental indexes of patients in corresponding subgroups of the main and comparison group did not differ significantly (p> 0.05).

By adding of new components we provide anti-inflammatory, capillary-membrane-stabilizing, wound-healing, anti-allergic, immune-modulating and hepatic-protective activity. Were ensured antimicrobial and antifungal activity of modified forms (min increase - 5,9%, max - 38,9%), increase saliva secretion rate to 2,08 ml/min, reducing its viscosity to 1,42 mPа×с, which is especially important for patients with HCV and IDA.

CONCLUSIONS: After treatment, periodontal indexes PBI and PDI were significantly lower (min decrease - 19,6%, max - 54,3%), in main group relative to the corresponding indicators of comparison group (p<0.05). This indicates positive effect of the use of modified complex for treatment and prophylaxis of chronic gingivitis and generalized periodontitis for patients with presence comorbidities. In spite of increasing cost of one dose the remission period increased twice (from 3 to 6 months).