OBJECTIVES

: The main of the study is to assess the need of dosage adjustments of thyroxine among pregnant women with hypothyroidism,To monitor fetomaternal outcome.

METHODS

: A Prospective observational study conducted in the department of Obstetrics and Gynaecology, from October 2017 to March 2018To evaluate the effects of pregnancy on thyroxine requirements, we prospectively reviewed the thyroid function of 86 women receiving treatment for hypothyroidism in pregnancy.

RESULTS

: Out of 86 subjects, 44 subjects are having pre pregnancy hypothyroidism and 42 subjects are having gestational hypothyroidism. Age at presentation (yrs) was 23.78+ 4.17; Weight (kgs) was 61.11+13.27. Among 44(51.16%) subjects in pre pregnancy hypothyroidism, 9(20.45%) subjects required increase in levothyroxine dose; 10(22.7%) required decrease in levothyroxine dose. Among 42(48.83%) subjects in gestational hypothyroidism, 5(11.9%) subjects required increase in levothyroxine dose; 2(4.76%) subjects required decrease in dose; (P=0.032). Remaining 60 subjects in both pre pregnancy and gestational hypothyroidism required no change due to sufficient dose. Among 86 subjects 59 subjects were delivered. Among these 23 subjects were anemic, 10 subjects were having oligohydramnios, 5 NICU admissions, 9 low birth weights of baby, 2 pre term deliveries, 3 neonatal deaths. 2 subjects were aborted.

CONCLUSIONS

: Based on our prospective observational study we finally conclude that Levothyroxine requirements was more in all trimesters but mostly in first trimester followed by third trimester. Levothyroxine requirement was more in Gestational hypothyroidism (19.76%) compared to Pre pregnancy hypothyroidism (16.27%). We also conclude that TSH level >10μIU/L has more number of low birth weights and abortions.