OBJECTIVES: To compare persistence and adherence to osteoporosis therapy as reported by patients against the same parameters measured through administrative healthcare data. METHODS: Patient-reported persistence and adherence to oral osteoporosis therapy were obtained from a Fracture Liaison Service managing patients with a recent fracture during follow-up visits (3, 6, 12, 18, 24 months). Data were collected for 2 years and both parameters were dichotomized (yes/no). Pharmacy data was also retrieved for the period. Patients were categorized as persistent to therapy if a claim was present in the 40 days preceding visits. Adherence was measured using the proportion of days covered (PDC) over the period between initiation in the last month before the visit up to the visit date. A PDC >