OBJECTIVES: Evidence on health utility in patients with major cardiovascular (CV) events is required for cost-utility analysis of CV prevention and treatment. This review aimed to identify and describe the utility values associated with MI/ACS reported in the available literature.

METHODS: An SLR was conducted to identify English publications in Embase^®, MEDLINE^® and the grey literature published in the last 10 years (2008-2017). Only primary studies reporting utilities for MI/ACS in adult patients were included. Two reviewers independently conducted the screening, data abstraction, and the quality assessment with a third reviewer consulted in case of any discrepancies. Utilities were evaluated by geography, methodology, and sub-groups (age and gender).

RESULTS: Thirty-one studies (sample size: 32 to 18,015) reported utilities across different geographies, including Europe (N=14), US (N=5), Asia (N=5), multi-national (N=4). Study country was not reported in 3 studies. Majority of studies used the EQ-5D assessment method (N=28), followed by SF-6D (N=3), SF-12, TTO, and 15D (N=1 each). In US, the utility values for MI/ACS ranged from 0.57 to 0.89, whereas in Europe, utilities varied from 0.43 to 0.94. The wide range was also seen with most commonly reported method of elicitation (EQ-5D: 0.43, 0.94). Throughout the time utility values tend to improve, but limited data is available in order to show a statistical significant improvement. Gender variation was observed as women showed lower utility values as compared to men, whilst older population (i.e. >60 years old) reported poorer quality-of-life than younger population.

CONCLUSIONS: This SLR identified the health utility values associated with MI/ACS and showed a due negative impact on quality-of-life of patients who suffered such CV events. Careful interpretation of published values is advised, given the heterogeneity of methodologies, patient populations and timing of utilities assessment reported in the available literature. Nevertheless, our results can be a valuable resource for future cost-utility analyses.