PILOT STUDY TO ESTABLISH PREFERENCES TOWARDS COAGULATION FACTOR CONCENTRATES USED TO TREAT HAEMOPHILIC PATIENTS WITH INHIBITORS

Author(s)

Luciana Scalone, PharmD, Researcher1, Alessandro Gringeri, MD, Associate Professor2, Francesca Borghetti, PharmD, Researcher Junior1, Simona Ravera, PharmD, Researcher1, Andrea Casati, PharmD, Researcher Junior1, Lorenzo Giovanni Mantovani, EconD, MSc, DSc, Researcher11Center of Pharmacoeconomics, University of Milan, Milan, Italy, Italy; 2 A. Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Found. Policlinico, Mangiagalli, Regina Elena Hosp. and Univ. of Milan, Milan, Italy, Italy

OBJECTIVES: Haemophilia is a very expensive disease. This situation becomes extreme when patients develop inhibitors that compromise the effectiveness of treatment, with potential increase of morbidity and mortality. Treatment of haemophilia is the result of interactions between patients, physicians, pharmacists and budget holders, each carrying their own set of preferences. A pilot study was conducted to identify which characteristic of coagulation products are considered more important to treat patients with inhibitors: these characteristics will be included with a price proxy characteristic in a Discrete Choice Experiment, with the objective to elicit preferences and willingness to pay towards treatments of patients with inhibitors. METHODS: Eight characteristics were identified during focus groups with patients and clinicians and rated from 0 (not important) to 10 (very important) by 35 people (adult patients, caregivers, physicians, pharmacists). RESULTS: the following median (mean) scores were found: “viral safety”: 10 (8.9); “time to stop bleeding”: 9.5 (9.0); “risk of anamnestic response”: 9.0 (8.5); “possibility of undergoing major surgery”: 9.0 (8.8); “regular use in prophylaxis”: 9.0 (8.4); “time to pain recovery”: 9.0 (8.3); “number of injections to stop bleeding”: 8.0 (7.9); “time to prepare and give/have the injection”: 7.0 (6.6). All groups of respondents considered as more important “viral safety”, “possibility of undergoing major surgery”, “risk of anamnestic response”, “time to stop bleeding”, while “time to prepare and give/have the injection” was considered the least important. Different preferences were attributed to “time to pain recovery”, considered more important by patients; “regular use in prophylaxis”, considered more important by caregivers. CONCLUSIONS: Viral safety and effectiveness are considered as the most important characteristics in the treatment of haemophilic patients with inhibitors. Different levels of preferences are present between patients, or their caregivers, and physicians. Understanding these differences is important to guide optimal therapeutic strategies in patients with inhibitors.

Conference/Value in Health Info

2006-05, ISPOR 2006, Philadelphia, PA

Value in Health, Vol. 9, No.3 (May/June 2006)

Code

PHM5

Topic

Patient-Centered Research

Topic Subcategory

Stated Preference & Patient Satisfaction

Disease

Systemic Disorders/Conditions

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