OBJECTIVES: To compare the performance of a disease specific satisfaction measure in overactive bladder (OAB-S) to the generic Treatment Satisfaction Questionnaire for Medication (TSQM). METHODS: The OAB-S consists of five scales (Expectations with OAB control, Control, Impact on daily living with OAB, Tolerability, and Satisfaction with OAB control) and five global questions related to expectation and satisfaction. The TSQM consists of four scales (Effectiveness, Convenience, Side effects and Global satisfaction). The questionnaires were administered to 134 subjects treated for their OAB with medication at baseline and two weeks later. RESULTS: All scales on both questionnaires satisfied the minimum recommended level for internal consistency reliability (Cronbach's alpha>0.70). The test re-test reliability of the all scales and individual items on the OAB-S showed good reliability (ICC>0.70; weighted Kappa >0.50); however only the Global satisfaction domain of the TSQM demonstrated good reliability (ICC=0.82). The ability of the questionnaires to discriminate among known groups of patients based on subject-reported OAB symptoms severity was tested and the relative validity (RV) was calculated. The RV was higher for the OAB-S scores compared to the TSQM scores of same content (e.g., TSQM Side effect RV=0.08 vs OAB-S Tolerability RV=0.20). The effect sizes for the domains related to the medication effectiveness were similar for both the TSQM and OAB-S (TSQM Effectiveness ES=0.26 vs. OAB Control ES=0.25); however, the effect sizes for the other domains were higher for the OAB-S compared to the TSQM indicating better responsiveness for the OAB-S. CONCLUSION: The OAB-S is better able to discriminate patients based on their OAB severity level, has better responsiveness to change and better reliability compared to the TSQM. The TSQM is a good measure that is appropriate to assess satisfaction across different disease states, while the OAB-S, a disease-specific measure of satisfaction, is preferable in trials with patients with OAB.