OBJECTIVES: Gastroesophageal reflux disease (GERD) is a chronic, potentially debilitating condition characterized by frequent and persistent heartburn and acid regurgitation. The objective of this study was to evaluate the effects of GERD on work productivity, defined as productivity loss due to absenteeism and reduced effectiveness while working (presenteeism). METHODS: Studies quantifying health-related work productivity loss in individuals with GERD were identified using systematic literature searches. Work productivity loss due to absenteeism was expressed as number of hours lost, and as the percentage of the total employed time. Presenteeism was expressed as number of hours lost, and as the percentage reduced effectiveness while at work. Overall productivity losses (absenteeism plus presenteeism) were valued in US dollars using the human capital method. RESULTS: Six publications covering five studies conducted in the USA, Canada and Sweden were eligible for inclusion. Reported work productivity losses among individuals with GERD ranged from 6% to 40%, and were primarily due to presenteeism (6% – 40%) rather than absenteeism ( < 1% – 6%). Work productivity impairment correlated with symptom severity, and was greatest in patients experiencing sleep disturbance due to GERD symptoms and lowest in GERD patients taking prescription medication. Acid-suppressive therapy improved productivity at work, especially in individuals with GERD-associated sleep disturbances. The mean overall productivity loss per employee with GERD was estimated at $51 – $396 per week, assuming a 40-hour working week and average US wages. CONCLUSION: GERD has a substantial economic impact, primarily by impairing employee productivity while at work. The burden of lost productivity may be reduced by acid-suppressive therapy, especially in employees with night-time symptoms of GERD.