OBJECTIVE: To assess the agreement between patients and carers (Familiar-FAM, Nurse-NUR and Physician-PH) on patients' HRQoL and to evaluate HRQoL and burden of FAM. METHODS: 221 patient-carer pairs stratified by age and gender were randomly selected from 14 dialysis units:152 hemodialysis-69 peritoneal dialysis. Patients' HRQoL was evaluated by patient and FAM,NUR and PH using EQ-5D(dimensions and Visual Analogue Scale-VAS). Patients and FAM answered the SF-36(PCS-MCS) and Duke-UNK Functional Social Support(FSS). FAM also answered Caregiver Burden Interview of Zarit(ZS); PH, the comorbidity Index of patients; and NUR, patientsx dependence in daily activities using the Barthel Scale(BS). RESULTS: The correlation coefficients between the VAS of the patients and their carers were 0.42(FAM), 0.49(NUR) and 0.30(PH); NUR and PH scored VAS higher than patients (p<0.01). The agreement (Kappa) between EQ-5D dimension scores varied between moderate for Mobility(0.56-FAM; 0.55-NUR; 0.47-PH) and Self-Care(0.48-FAM; 0.50-NUR; 0.42-PH) and low or insignificant for Pain(0.32-FAM; 0.40-NUR; 0.18-PH) and Anxiety/Depression(0.26-FAM; 0.28-NUR; 0.14-PH). The variables associated to the difference between the VAS score of patient and carers were studied using lineal regression. Mean(S.D) PCS and MCS of caregivers were 48.4(13.8) and 48.0(11.3). Multiple regression analysis showed that higher ZS and older patient age were associated to lower PCS of the caregiver(R2=0.15;p<0.001) and that higher ZS and lower FSS of the caregiver, and lower MCS of the patient were associated to lower MCS of the caregiver(R2=0.29;p<0.001). Lower FSS, PCS and MCS of the caregiver and higher age and lower PCS and MCS of the patient were associated to higher score on ZS of caregivers(R2=0.49;p<0.001). CONCLUSIONS: Agreement between patients and carers was moderate for “objective” dimensions of HRQOL and low for “subjective” ones. HRQoL of FAM is slightly worse than that of the general population.The burden of FAM depends on perceived social support, patientxs age and health status of carer and patient.